Therapeutic Tolerance Workshop 26-28 June 2013
In June 2013 we will host the third international workshop on Clinical Therapeutic Tolerance. The first, in June 2005 was entitled ‘Therapeutic Tolerance: Myth or Reality?’ In 2009 we entitled our workshop ‘Therapeutic Tolerance: Closer to Reality?’ For 2013 we have put together a further exciting programme, when we can start to discuss our attempts to induce and to measure therapeutic tolerance in the clinic. We have invited speakers from across the autoimmunity, transplantation and allergy fields and our provisional programme is attached.
THERAPEUTIC TOLERANCE: INDUCING STRATEGIES IN THE CLINIC
The Third Newcastle Therapeutic Tolerance Workshop
26th-28th June 2013, Newcastle upon Tyne
PROVISIONAL PROGRAMME
Wednesday 26th June - Research Beehive, Newcastle University
Wednesday morning – delegates arrive for registration
| Session 1- Tolerance Mechanisms
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| Dan Littman (New York, USA) | The Microbiome and Tolerance | |||
| Georg Holländer (Oxford, UK) | Central Tolerance Mechanisms | |||
| Steve Cobbold (Oxford, UK) | Peripheral Tolerance Mechanisms | |||
| Alan Mowatt (Glasgow, UK) | Mucosal Tolerance Mechanisms | |||
| Session 2- Tolerance Mechanisms
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| Peter Krammer (Heidelberg, Germany) | Apoptosis and therapeutic tolerance | |||
| Steve Anderton (Edinburgh, UK) | Tolerance and autoimmunity – interrogating the players | |||
| Anne Cooke (Cambridge, UK) | Tolerance breakdown in murine diabetes | |||
| Iain McInnes (Glasgow, UK) | Investigating immune tolerance – a systems biology approach | |||
| Discussion | ||||
| Buffet dinner (Great North Museum) | ||||
Thursday 27th June - Research Beehive, Newcastle University
| Session 3- Cells and the maintenance of tolerance
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| Ethan Shevach (Maryland, USA) | Regulatory T Cells | ||||
| Simon Fillatreau (Berlin, Germany) | B Cells and tolerance | ||||
| Herman Waldmann (Oxford, UK | Cellular metabolism and tolerance | ||||
| Chris Buckley (Birmingham, UK) | The role of the stroma in immune tolerance | ||||
| Matthew Collin (Newcastle, UK) | Skin dendritic cells and graft versus host disease | ||||
| Discussion | |||||
| Session 4 – Immune modulating strategies in the clinic
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| Lucienne Chatenoud (Paris, France) | Anti-CD3 Therapy to Induce Tolerance | ||||
| Joanna Jones (Cambridge, UK) | Depletional tolerance in multiple sclerosis | ||||
| Thomas Wekerke (Vienna, Austria) | Costimulation blockade in man, mechanisms and outcomes | ||||
| Michael Ehrenstein (London, UK) | Manipulating cytokines to induce tolerance | ||||
| Discussion | |||||
| Session 5 – Immune modulating strategies in the clinic
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| David Wraith (Bristol, UK) | Peptide Induced Tolerance | ||||
| Mark Larche (Ontario, Canada) | Peptide therapy of allergy with a focus on response biomarkers | ||||
| Berent Prakken (Utrecht Netherlands) | Heat shock proteins and tolerance | ||||
| Jacob van Laar (Newcastle, UK) | Autologous stem cell transplantation | ||||
| Sir Roy Calne (Cambridge, UK)
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Prope tolerance – how near can we get? | ||||
| Discussion | |||||
| Debate | |||||
| Dinner (The Life Centre) | |||||
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Friday 28th June - Research Beehive, Newcastle University
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| Session 6 – Maximising clinical benefits of tolerogenic therapies
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| Andrew Mellor (Georgia, USA) | Indoleamine dioxygenase and tolerance | ||||
| Robert Lechler (London, UK) | Biomarker of tolerance induction | ||||
| Andrew Cope (London, UK) | Can we define a true remission state in RA? | ||||
| Alberto Sanchez-Fueyo (London, UK) | Iron metabolism and transplantation tolerance | ||||
| John Isaacs (Newcastle, UK) | Getting the timing right | ||||
| David Wofsy (California, USA) | Designing a therapeutic tolerance trial | ||||
| Discussion | |||||
| Session 7 – Tolerogenic dendritic cells
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| Ranjeny Thomas (Brisbane, Australia) | Tolerogenic DCs in rheumatoid arthritis | |
| Catharien Hilkens (Newcastle, UK) | AuToDeCRA | |
| Angus Thomson (Pittsburgh, USA) | Tolerogenic dendritic cells in transplantation | |
| Discussion | ||
| Session 8 – Cellular Therapies
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| Kathryn Wood (Oxford, UK) | Regulatory T cell in transplantation | |
| Giovanna Lombardi (London, UK) | Optimising therapy with regulatory T cells | |
| David Klatzmann (Paris, France) | Interleukin-2 and regulatory T cell expansion | |
| Alan Tyndall (Basel, Switzerland) | Mesenchymal Stem Cells - The Holy Grail | |
| Discussion | ||
| Closing remarks | ||
Poster Presentations
Abstract submission deadline 14th March 2013
For those wishing to submit a poster presentation, please provide a 350 word abstract (no more than 1 side of A4), with up to 1 figure or table and include subheadings (Objectives, Methods, Results, Discussion).
Abstracts should be sent to lisa.tait@ncl.ac.uk (you will hear before the end of March whether your abstract has been accepted).
For further information please contact Lisa Tait (lisa.tait@ncl.ac.uk) or to register please visit our webstore at http://webstore.ncl.ac.uk/browse/extra_info.asp?compid=1&modid=2&prodid=193&deptid=9&catid=42
Places are limited so please make sure you register soon to avoid disappointment.
Tags: therapeutic, Tolerance, workshop
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