Abstracts and Posters from the 22nd February 2008 meeting in Hertfordshire, UK
Chair: Professor George Salmond, University of Cambridge, UK
Editors: Dr Nicholas Warrick and Dr Shara Cohen
Bacteriophages (phages) are obligate molecular parasites of their hosts, the bacteria and they are, arguably, the most abundant biological entities on Earth. Many years of basic research on the nature of phages have provided a wealth of information on fundamental molecular processes in bacteria. As a spin-off from such “pure science” studies, bacteriophage research has been exploited to generate a spectrum of technologies and reagents that have underpinned the development of modern biotechnology (at lab scale and in industrial bioprocesses). Indeed, the power of modern biology research would have been unimaginable without the translation of phage research into generic techniques and molecular tools with widespread applicability. Largely driven by bacterial genomic research, in recent years there has been resurgence in interest in phages because of their roles as key drivers of adaptive evolution in their bacterial hosts, particularly affecting virulence. Furthermore, there has been stimulation of phage research because of the possibilities of exploiting phages in multiple ways - including as delivery agents for vaccine development, and in “phage therapy”. Professor George Salmond, University of Cambridge, UK
Introduction: The wonderful world of bacteriophages
The impact of bacteriophage on bacterial genome evolution
STX-phages and virulence gene dissemination in pathogens
Bacteriophage abortive infection systems
Novel anti-phage systems in bacteria
Use of phages for detection of bacterial pathogens
Biotechnological challenges of phage therapy
Immune responses following treatment with bacteriophage
Does phage therapy actually work? Results from the first phase 2 clinical trial
POSTER PRESENTATIONS
Aspects of large scale filamentous bacteriophage production: Particle characterisation, contained fermentation and primary recovery
Biocontrol of E. coli O157:H7: Genome sequencing of two anti-E. coli O157:H7 bacteriophages
Metagenomic analysis of the human tongue dorsum using phage display
Isolation of a cloned bacteriophage lysin (LysK) which eliminates pathogenic staphylococci including MRSA
Characterization of the bacteriophage-related gene clusters in the genome of a cystic fibrosis epidemic strain of pseudomonas aeruginosa
Characterization of bacteriophages active against pseudomonas aeruginosa
Isolation and characterization of bacteriophages with potential to control lactic acid bacterial strains which cause spoilage in brewing processes
The impact of prophages on citrobacter rodentium
The potential therapy of immobilised bacteriophage on sutures in a methicillin resistant Staphylococcus aureus (MRSA) wound model
The large scale fermentation and bioprocessing of bacteriophage
Citrobacter rodentium phages: Characterization and screening for phage therapy applications
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